Statistical Modeling And Machine Learning For Molecular Biology

Download or read book Statistical Modeling and Machine Learning for Molecular Biology written by Alan Moses and published by Chapman & Hall/CRC. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers several of the major data analysis techniques used to analyze data from high-throughput molecular biology and genomics experiments. It also explains the major concepts behind most of the popular techniques and examines some of the simpler techniques in detail.

Download or read book Statistical Modeling and Machine Learning for Molecular Biology written by Alan Moses and published by CRC Press. This book was released on 2017-01-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: • Assumes no background in statistics or computers • Covers most major types of molecular biological data • Covers the statistical and machine learning concepts of most practical utility (P-values, clustering, regression, regularization and classification) • Intended for graduate students beginning careers in molecular biology, systems biology, bioengineering and genetics

Download or read book Gene Expression Data Analysis written by Pankaj Barah and published by CRC Press. This book was released on 2021-11-08 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of high-throughput technologies in molecular biology during the last two decades has contributed to the production of tremendous amounts of data. Microarray and RNA sequencing are two such widely used high-throughput technologies for simultaneously monitoring the expression patterns of thousands of genes. Data produced from such experiments are voluminous (both in dimensionality and numbers of instances) and evolving in nature. Analysis of huge amounts of data toward the identification of interesting patterns that are relevant for a given biological question requires high-performance computational infrastructure as well as efficient machine learning algorithms. Cross-communication of ideas between biologists and computer scientists remains a big challenge. Gene Expression Data Analysis: A Statistical and Machine Learning Perspective has been written with a multidisciplinary audience in mind. The book discusses gene expression data analysis from molecular biology, machine learning, and statistical perspectives. Readers will be able to acquire both theoretical and practical knowledge of methods for identifying novel patterns of high biological significance. To measure the effectiveness of such algorithms, we discuss statistical and biological performance metrics that can be used in real life or in a simulated environment. This book discusses a large number of benchmark algorithms, tools, systems, and repositories that are commonly used in analyzing gene expression data and validating results. This book will benefit students, researchers, and practitioners in biology, medicine, and computer science by enabling them to acquire in-depth knowledge in statistical and machine-learning-based methods for analyzing gene expression data. Key Features: An introduction to the Central Dogma of molecular biology and information flow in biological systems A systematic overview of the methods for generating gene expression data Background knowledge on statistical modeling and machine learning techniques Detailed methodology of analyzing gene expression data with an example case study Clustering methods for finding co-expression patterns from microarray, bulkRNA, and scRNA data A large number of practical tools, systems, and repositories that are useful for computational biologists to create, analyze, and validate biologically relevant gene expression patterns Suitable for multidisciplinary researchers and practitioners in computer science and the biological sciences

Download or read book Learning and Inference in Computational Systems Biology written by Neil D. Lawrence and published by . This book was released on 2010 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tools and techniques for biological inference problems at scales ranging from genome-wide to pathway-specific. Computational systems biology unifies the mechanistic approach of systems biology with the data-driven approach of computational biology. Computational systems biology aims to develop algorithms that uncover the structure and parameterization of the underlying mechanistic model--in other words, to answer specific questions about the underlying mechanisms of a biological system--in a process that can be thought of as learning or inference. This volume offers state-of-the-art perspectives from computational biology, statistics, modeling, and machine learning on new methodologies for learning and inference in biological networks.The chapters offer practical approaches to biological inference problems ranging from genome-wide inference of genetic regulation to pathway-specific studies. Both deterministic models (based on ordinary differential equations) and stochastic models (which anticipate the increasing availability of data from small populations of cells) are considered. Several chapters emphasize Bayesian inference, so the editors have included an introduction to the philosophy of the Bayesian approach and an overview of current work on Bayesian inference. Taken together, the methods discussed by the experts in Learning and Inference in Computational Systems Biology provide a foundation upon which the next decade of research in systems biology can be built. Florence d'Alch e-Buc, John Angus, Matthew J. Beal, Nicholas Brunel, Ben Calderhead, Pei Gao, Mark Girolami, Andrew Golightly, Dirk Husmeier, Johannes Jaeger, Neil D. Lawrence, Juan Li, Kuang Lin, Pedro Mendes, Nicholas A. M. Monk, Eric Mjolsness, Manfred Opper, Claudia Rangel, Magnus Rattray, Andreas Ruttor, Guido Sanguinetti, Michalis Titsias, Vladislav Vyshemirsky, David L. Wild, Darren Wilkinson, Guy Yosiphon

Download or read book Modern Statistics for Modern Biology written by SUSAN. HUBER HOLMES (WOLFGANG.) and published by Cambridge University Press. This book was released on 2018 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Introduction to Machine Learning and Bioinformatics written by Sushmita Mitra and published by CRC Press. This book was released on 2019-08-30 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lucidly Integrates Current Activities Focusing on both fundamentals and recent advances, Introduction to Machine Learning and Bioinformatics presents an informative and accessible account of the ways in which these two increasingly intertwined areas relate to each other. Examines Connections between Machine Learning & Bioinformatics The book begins with a brief historical overview of the technological developments in biology. It then describes the main problems in bioinformatics and the fundamental concepts and algorithms of machine learning. After forming this foundation, the authors explore how machine learning techniques apply to bioinformatics problems, such as electron density map interpretation, biclustering, DNA sequence analysis, and tumor classification. They also include exercises at the end of some chapters and offer supplementary materials on their website. Explores How Machine Learning Techniques Can Help Solve Bioinformatics Problems Shedding light on aspects of both machine learning and bioinformatics, this text shows how the innovative tools and techniques of machine learning help extract knowledge from the deluge of information produced by today's biological experiments.

Download or read book Machine Learning with R written by Brett Lantz and published by Packt Publishing Ltd. This book was released on 2019-04-15 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solve real-world data problems with R and machine learning Key Features Third edition of the bestselling, widely acclaimed R machine learning book, updated and improved for R 3.6 and beyond Harness the power of R to build flexible, effective, and transparent machine learning models Learn quickly with a clear, hands-on guide by experienced machine learning teacher and practitioner, Brett Lantz Book Description Machine learning, at its core, is concerned with transforming data into actionable knowledge. R offers a powerful set of machine learning methods to quickly and easily gain insight from your data. Machine Learning with R, Third Edition provides a hands-on, readable guide to applying machine learning to real-world problems. Whether you are an experienced R user or new to the language, Brett Lantz teaches you everything you need to uncover key insights, make new predictions, and visualize your findings. This new 3rd edition updates the classic R data science book to R 3.6 with newer and better libraries, advice on ethical and bias issues in machine learning, and an introduction to deep learning. Find powerful new insights in your data; discover machine learning with R. What you will learn Discover the origins of machine learning and how exactly a computer learns by example Prepare your data for machine learning work with the R programming language Classify important outcomes using nearest neighbor and Bayesian methods Predict future events using decision trees, rules, and support vector machines Forecast numeric data and estimate financial values using regression methods Model complex processes with artificial neural networks — the basis of deep learning Avoid bias in machine learning models Evaluate your models and improve their performance Connect R to SQL databases and emerging big data technologies such as Spark, H2O, and TensorFlow Who this book is for Data scientists, students, and other practitioners who want a clear, accessible guide to machine learning with R.