Receptor-Receptor Interactions

Receptor-Receptor Interactions
Author :
Publisher : Springer Science & Business Media
Total Pages : 577
Release :
ISBN-10 : 9781468454154
ISBN-13 : 1468454153
Rating : 4/5 (54 Downloads)

Book Synopsis Receptor-Receptor Interactions by : Kjell Fuxe

Download or read book Receptor-Receptor Interactions written by Kjell Fuxe and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Affinity and Efficacy

Affinity and Efficacy
Author :
Publisher : World Scientific Publishing Company Incorporated
Total Pages : 739
Release :
ISBN-10 : 9814322563
ISBN-13 : 9789814322560
Rating : 4/5 (63 Downloads)

Book Synopsis Affinity and Efficacy by : Frederick J. Ehlert

Download or read book Affinity and Efficacy written by Frederick J. Ehlert and published by World Scientific Publishing Company Incorporated. This book was released on 2014-09-15 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interaction of a drug with a receptor encodes a vector of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drugreceptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is shed on ligand-gated ion channels and G protein-coupled receptors in this book. The topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, ligand-directed signaling, modulation of pathway selectivity, and the analysis of the loss of function in tissues from receptor knockout mice. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed.

Toxicant-Receptor Interactions

Toxicant-Receptor Interactions
Author :
Publisher : CRC Press
Total Pages : 243
Release :
ISBN-10 : 1560326336
ISBN-13 : 9781560326335
Rating : 4/5 (36 Downloads)

Book Synopsis Toxicant-Receptor Interactions by : Michael Denison

Download or read book Toxicant-Receptor Interactions written by Michael Denison and published by CRC Press. This book was released on 1998-08-10 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are directly related to the analysis of the molecular mechanism by which xenobiotics modulate signal transduction and gene expression.

Receptor Binding Techniques

Receptor Binding Techniques
Author :
Publisher : Humana
Total Pages : 240
Release :
ISBN-10 : 158829420X
ISBN-13 : 9781588294203
Rating : 4/5 (0X Downloads)

Book Synopsis Receptor Binding Techniques by : Anthony P. Davenport

Download or read book Receptor Binding Techniques written by Anthony P. Davenport and published by Humana. This book was released on 2005-03-25 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand binding assays and their analysis, quantitative autoradiography, and imaging receptors by positron emission tomography (PET). Highlights include phenotypic characterization of receptors in knockout mice, imaging receptors using green fluorescent protein and fluorescent resonance energy transfer, and quantitative analysis of receptor mRNA by TaqMan PCR. These book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified.

Textbook of Receptor Pharmacology

Textbook of Receptor Pharmacology
Author :
Publisher : CRC Press
Total Pages : 314
Release :
ISBN-10 : 9781420052558
ISBN-13 : 1420052551
Rating : 4/5 (58 Downloads)

Book Synopsis Textbook of Receptor Pharmacology by : John C. Foreman

Download or read book Textbook of Receptor Pharmacology written by John C. Foreman and published by CRC Press. This book was released on 2010-09-10 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classica

Frontiers in Pharmacology of Neurotransmitters

Frontiers in Pharmacology of Neurotransmitters
Author :
Publisher : Springer Nature
Total Pages : 729
Release :
ISBN-10 : 9789811535567
ISBN-13 : 9811535566
Rating : 4/5 (67 Downloads)

Book Synopsis Frontiers in Pharmacology of Neurotransmitters by : Puneet Kumar

Download or read book Frontiers in Pharmacology of Neurotransmitters written by Puneet Kumar and published by Springer Nature. This book was released on 2020-10-29 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

Drug-Acceptor Interactions

Drug-Acceptor Interactions
Author :
Publisher : CRC Press
Total Pages : 847
Release :
ISBN-10 : 9781351660570
ISBN-13 : 1351660578
Rating : 4/5 (70 Downloads)

Book Synopsis Drug-Acceptor Interactions by : Niels Bindslev

Download or read book Drug-Acceptor Interactions written by Niels Bindslev and published by CRC Press. This book was released on 2017-02-10 with total page 847 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.