Fatal Inheritance

Download or read book A Fatal Inheritance written by Lawrence Ingrassia and published by Henry Holt and Company. This book was released on 2024-05-14 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation. Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni’s initial discoveries, and to understand what this means for their families. In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to “fight like Charlie,” his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.

Download or read book Fatal Inheritance written by Rachel Rhys and published by Simon and Schuster. This book was released on 2019-06-11 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get swept away to the enchanting South of France with this “exquisite and shimmering” (Lisa Jewell, New York Times bestselling author of Then She Was Gone) suspenseful historical novel, where perilous secrets lurk under the glitz and glam of seaside wealth. She didn’t have an enemy in the world…until she inherited a fortune. London 1948: Eve Forrester is stuck in a loveless marriage, isolated in her gray and gloomy house when out of the blue, she receives a letter. A wealthy stranger has left her a mysterious inheritance but in order to find out more, she must travel to the glittering French Riviera. There, Eve discovers she has been bequeathed an enchanting villa overlooking the Mediterranean Sea and suddenly, life could not be more glamorous. But while she rubs shoulders with the rich and famous, challengers to her unexplained fortune begin to emerge—challengers who would love to see Eve gone forever. Alone in paradise, Eve must unlock the story behind her surprise bequest—before her unexpected twist of fate turns deadly… With Rachel Rhys’s “thrilling, seductive, and utterly absorbing” (Paula Hawkins, #1 bestselling author of The Girl on the Train) prose, Fatal Inheritance is an intoxicating story of dysfunctional families and long-hidden secrets, set against the decadence of the Côte d’Azur.

Download or read book The Family Gene written by Joselin Linder and published by HarperCollins. This book was released on 2017-03-14 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.

Download or read book Crown of Thistles written by Linda Porter and published by Pan Macmillan. This book was released on 2013-08-15 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: The struggle between the fecund Stewarts and the barren Tudors is generally seen only in terms of the relationship between Elizabeth I and her cousin, Mary Queen of Scots. But very little has been said about the background to their intense rivalry. Here, Linda Porter examines the ancient and intractable power struggle between England and Scotland, a struggle intensified during the reigns of Elizabeth and Mary's grandfathers. Henry VII aimed to provide stability when he married his daughter, Margaret, to James IV of Scotland in 1503. But he must also have known that Margaret's descendants might seek to rule the entire island. Crown of Thistles is the story of a divided family, of flamboyant kings and queens, cultured courts and tribal hatreds, blood feuds, rape and sexual licence on a breath-taking scale, and violent deaths. It also brings alive a neglected aspect of British history - the blood-spattered steps of two small countries on the fringes of Europe towards an awkward unity that would ultimately forge a great nation. Beginning with the unlikely and dramatic victories of two usurping kings, one a rank outsider and the other a fourteen-year-old boy who rebelled against his own father, the book sheds new light on Henry VIII, his daughter, Elizabeth, and on his great-niece, Mary Queen of Scots, still seductive more than 400 years after her death.

Download or read book A Dangerous Crossing written by Rachel Rhys and published by Random House Australia. This book was released on 2017-04-03 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'An exquisite story of love, murder, adventure and dark secrets, Rachel Rhys brings this dangerous crossing brilliantly and beautifully alive' LISA JEWELL 'Thrilling, seductive, utterly absorbing' PAULA HAWKINS England, September 1939 Lily Shepherd boards a cruise liner for a new life in Australia and is plunged into a world of cocktails, jazz and glamorous friends. But as the sun beats down, poisonous secrets begin to surface. Suddenly Lily finds herself trapped with nowhere to go ... Australia, six weeks later The world is at war, the cruise liner docks, and a beautiful young woman is escorted onto dry land in handcuffs. What has she done? 'Thrilling, captivating. Simply stunning' Daily Express 'It is written so beautifully it seems to glide by way too quickly, transporting you on a journey you won't want to end' Sunday Mirror 'Rhys creates such a powerful sense of foreboding that you may well gulp down the entire book in a single day' The Irish Times

Download or read book The Inheritance written by Niki Kapsambelis and published by Simon and Schuster. This book was released on 2017-03-07 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This gripping story of the doctors at the forefront of Alzheimer’s research and the courageous North Dakota family whose rare genetic code is helping to understand our most feared diseases is “excellent, accessible...A science text that reads like a mystery and treats its subjects with humanity and sympathy” (Library Journal, starred review). Every sixty-nine seconds, someone is diagnosed with Alzheimer’s disease. Of the top ten killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer’s, an inherited genetic mutation that causes the disease in one hundred percent of cases, and has a fifty percent chance of being passed onto the next generation. Of the six DeMoe children whose father had it, five have inherited the gene; the sixth, daughter Karla, has inherited responsibility for all of them. But rather than give up in the face of such news, the DeMoes have agreed to spend their precious, abbreviated years as part of a worldwide study that could utterly change the landscape of Alzheimer’s research and offers the brightest hope for future treatments—and possibly a cure. Drawing from several years of in-depth research with this charming and upbeat family, journalist Niki Kapsambelis tells the story of Alzheimer’s through the humanizing lens of these ordinary people made extraordinary by both their terrible circumstances and their bravery. “A compelling narrative…and an educational and emotional chronicle” (Kirkus Reviews, starred review), their tale is intertwined with the dramatic narrative history of the disease, the cutting-edge research that brings us ever closer to a possible cure, and the accounts of the extraordinary doctors spearheading these groundbreaking studies. From the oil fields of North Dakota to the jungles of Colombia, this inspiring race against time redefines courage in the face of this most pervasive and mysterious disease.

Download or read book Altered Inheritance written by Françoise Baylis and published by Harvard University Press. This book was released on 2019-09-17 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading bioethicist offers critical insights into the scientific, ethical, and political implications of human genome editing. Designer babies, once found only in science fiction, have become a reality. We are entering a new era of human evolution with the advent of a technology called CRISPR, which allows scientists to modify our genes. Although CRISPR shows great promise for therapeutic use, it raises thorny ethical, legal, political, and societal concerns because it can be used to make permanent changes to future generations. What if changes intended for the good turn out to have unforeseen negative effects? What if the divide between the haves and have-nots widens as a result? Who decides whether we genetically modify human beings and, if so, how? Françoise Baylis insists that we must all have a role in determining our future as a species. The scientists who develop and use genome-editing tools should not be the only ones making decisions about future uses of the technology. Such decisions must be the fruit of a broad societal consensus. Baylis argues that it is in our collective interest to assess and steer the development and implementation of biomedical technologies. Members of the public with different interests and diverse perspectives must be among the decision makers; only in this way can we ensure that societal concerns are taken into account and that responsible decisions are made. We must be engaged and informed, think critically, and raise our voices as we create our future together. Sharp, rousing, timely, and thought-provoking, Altered Inheritance is essential reading. The future of humanity is in our hands.