Combinatorial Chemistry And Technology

Download or read book Combinatorial Chemistry and Technologies written by Stanislav Miertus and published by CRC Press. This book was released on 2005-04-12 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the

Download or read book Combinatorial Chemistry written by Stephen R. Wilson and published by John Wiley & Sons. This book was released on 1997-03-28 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Download or read book Combinatorial Chemistry written by Nicholas K. Terrett and published by . This book was released on 1998 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.

Download or read book Combinatorial Chemistry and Technology written by Stanislav Miertus and published by CRC Press. This book was released on 1999-07-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

Download or read book Combinatorial Synthesis of Natural Product-Based Libraries written by Armen M. Boldi and published by CRC Press. This book was released on 2006-05-16 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato

Download or read book Combinatorial Chemistry and Technologies written by Stanislav Miertus and published by CRC Press. This book was released on 2005-04-12 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Download or read book A Handbook for DNA-Encoded Chemistry written by Robert A. Goodnow, Jr. and published by John Wiley & Sons. This book was released on 2014-04-28 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods