Opioid Peptides

Download or read book Opioids and Their Receptors written by Mariana Spetea and published by MDPI. This book was released on 2020-12-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

Download or read book Neurobiology of Alcohol Dependence written by Antonio Noronha and published by Elsevier. This book was released on 2014-05-02 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. - Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels - Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence - Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Download or read book Regulatory Roles of Opioid Peptides written by Peter Illes and published by John Wiley & Sons. This book was released on 1988 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bioactive Peptides written by John Oloche Onuh and published by CRC Press. This book was released on 2021-06-15 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive peptides have been receiving attention recently due to their applications as health-promoting agents. Derived from food proteins and other natural sources, they exhibit various beneficial effects such as preventing diseases or modulating physiological systems once absorbed. As the market for nutraceuticals and functional foods continues to expand, consumer interest has also grown and there are many common foods that have shown an abundance of bioactive peptides, including dairy products, cereal, legumes, meat, and numerous other sources. In this newest addition to the series Nutraceuticals: Basic Research and Clinical Applications, Bioactive Peptides: Production, Bioavailability, Health Potential, and Regulatory Issues provides a comprehensive review of the current state of knowledge in the field of food protein hydrolysates and bioactive peptides, their food sources, bioavailability, production, applications, functionalities, health potentials, and regulatory issues governing their use. Features Discusses different methodologies employed for scaling up bioactive peptides commercially Provides information on optimizing the production process Explains various bioactive properties exerted by different types of bioactive peptides Explores the application of metabolomics to the study of bioactive peptides With over 20 chapters written by established subject matter experts in their field, this book provides timely information and discusses the latest developments of bioactive peptides. It will be useful for researchers, academics, and industry experts, and can serve as an excellent resource for anyone interested in enhancing their knowledge in the field of bioactive peptides.

Download or read book Acupuncture Therapy for Neurological Diseases written by Ying Xia and published by Springer Science & Business Media. This book was released on 2010-09-08 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acupuncture therapy has been practiced in China and other Asian countries for more than two thousand years. Modern clinical research has confirmed the impressive therapeutic effect of acupuncture on numerous human ailments, such as controlling pain, nausea, and vomiting. However, the biological mechanisms of acupuncture are still under debate. In Traditional Chinese Medicine (TCM), the mechanism of acupuncture therapy is explained by a meridian model. According to this model, acupuncture is believed to treat the diseased organs by modulating two conditions known as Yin and Yang, which represent all the opposite principles that people find in the universe, both inside and outside the human body. Yin and Yang complement each other, and are subjected to changes between each other. The balance of Yin and Yang is thought to be maintained by Qi, an energy substance flowing constantly through the meridian, a network connecting all the organs of the body. The illness, according to this theory, is the temporary dominance of one principle over the other, owing to the blockade of the Qi from flowing through the meridian under certain circumstance. The axiom of “No stagnation, No pain” in TCM summarizes this concept. Thus, the goal of acupuncture treatment is to restore the balance of Yin and Yang conditions in the diseased organ(s). This theory has been considered to be useful to guide this ancient therapy, such as carrying out diagnosis, deciding on the principle, and selecting the acupoints.

Download or read book Endorphins in Mental Health Research written by Earl Usdin and published by Springer. This book was released on 2016-01-14 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: